Olympic 800m champion Keely Hodgkinson continued to work on her first-lap speed by competing in the 400m.
Charlotte Henrich won her heat in a personal best of 51.20 seconds but Hodgkinson's time of 51.62 was enough for her to also qualify for Sunday's final (16:06 BST).
Matthew Hudson-Smith, the 2024 Olympic 400m silver medallist, won his heat in 45.24 to become the fastest qualifier for the men's final (15:48 BST).
One of the stands has been named after the US-based Wolverhampton native for the national and European Championships.
"I love being here," he said. "I put the bat signal out yesterday, 'I'm back in Birmingham!' Everyone wanted to see me.
"I just want to go out, but I've got a job to do, then after I will go and see people."
Joel Clarke-Khan shed tears of joy after equalling his personal best to win the men's high jump.
After winning three outdoor British titles between 2020 and 2023, Clarke-Hunt endured an injury-plagued 18 months with toe problems.
But after claiming the national indoor title in February, the 26-year-old continued an impressive year by jumping 2.27 metres in Birmingham.
"That is something I've dreamed about forever really," he said. "It's been a really long journey back from 2022. I'm just over the moon to be here today like this.
"I've been working so hard for this moment. The 2.27 really makes me believe that I'm back to where I've been before, so I'm really excited for the future."
Marcia Sey set a championship record of 12.65 secs to win the 100m hurdles while Elise Thorner lowered her own championship record in the 3000m steeplechase to nine minutes 16.95 seconds.
Lawrence Okoye was a dominant winner of the men's discus with a championship record of 68.81 metres and Stephen Mackenzie set a Scottish-record 8.15m in the men's long jump.

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